Normal Functional Protein S Activity Does Not Exclude Protein S Deficiency
نویسندگان
چکیده
منابع مشابه
An abnormal plasma distribution of protein S occurs in functional protein S deficiency.
Protein S is a natural anticoagulant present in the plasma that serves as a cofactor for activated protein C. Patients deficient in protein S are subject to recurrent venous thrombotic disease. Protein S deficiency differs from other plasma protein deficiencies in that deficient patients often have normal or only mildly reduced levels of protein S in their plasma as detected by conventional imm...
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Abstract Arterial ischemic stroke defines as a new focal neurologic deficit that lasted 24 hours or longer. Stroke is relatively rare in children and incidence of cerebrovascular disease is 1 per 4000 in neonates and 1 per 7000 to 1 per 70000 in older children (1 month to 18 years). Protein S deficiency is one of the causes of the stroke in children. Major manifestations of protein S deficienc...
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Protein S deficiency (PSD) has been the most difficult to study among the classical inherited thrombophilic factors. This is in part due to the peculiar biology of protein S (PS), which has an anticoagulant role but no enzymatic activity, and because it interacts with plasma components that function in both haemostasis and inflammation. Clinically, it also has been difficult to define and stand...
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متن کاملStroke and familial protein S deficiency.
To the Editor: We have read with special attention the letter of Davous et al. Because the association between hereditary protein S deficiency and cerebral arterial thrombosis is controversial,' we are reporting another case with this same association in which other members of the family were affected by arterial thrombotic diseases. A 44-year-old man was admitted to our hospital a few hours af...
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ژورنال
عنوان ژورنال: Pathophysiology of Haemostasis and Thrombosis
سال: 2003
ISSN: 1424-8832,1424-8840
DOI: 10.1159/000081509